منابع مشابه
Transcription factor-mediated epigenetic reprogramming.
Input from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induc...
متن کاملPioneer transcription factors in cell reprogramming.
A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram one type of cell into another. The transcription factors that reprogram cell fate are invariably those that are crucial for the initial cell programming in embryonic development. To elicit cell programming or reprogramming, transcription factors must be able to engage genes that are developmentally silenc...
متن کاملCooperative Binding of Transcription Factors Orchestrates Reprogramming
Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To gain a mechanistic understanding of their function, we mapped OSKM-binding, stage-specific transcription factors (TFs), and chromatin states in discrete reprogramming stages and performed loss- and gain-of-function experiments. We found that OSK predominantly bind active somatic enhancers early in reprogramming and im...
متن کاملnetwork analysis of transcription factors for nuclear reprogramming into induced pluripotent stem cell using bioinformatics
objective: research related to induce pluripotent stem (ips) cell generation has increased rapidly in recent years. six transcription factors, namely oct4, sox2, c-myc, klf4, nanog, and lin28 have been widely used for ips cell generation. as there is a lack of data on intra- and inter-networking among these six different transcription factors, the objective of this study is to analyze the intra...
متن کاملStoichiometry of transcription factors is critical for cardiac reprogramming.
D irect reprogramming of fibroblasts into cardiomyocytes holds great potential for cardiovascular disease research and treatment. This new technology may be used for patient-specific drug screening, cardiac disease modeling, and regen-erative purposes. We reported first that a combination of 3 cardiac-specific transcription factors, Gata4 (G), Mef2c (M), and Tbx5 (T), constituted the minimum re...
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ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/383763a0